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. 2017 Mar 10;7:141. doi: 10.1038/s41598-017-00207-7

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The NRG1-ErbB4 pathway regulates phosphorylation of GluN2B through Src kinase in human tissues. (a) Ecto-ErbB4 (2 μg/ml) treatment simultaneously increased GluN2B-pY1472 and Src-pY416 in human brain slices. (b) Quantification of GluN2B-pY1472 immunoblots (n = 5). (c and d) Pretreatment with the Src inhibitor PP2 prevents the increase of Glu2B-pY1472 induced by ecto-ErbB4 (n = 3). *P < 0.05. Unpaired two-tailed Student’s t-test. Data are represented as the mean ± s.e.m.