Fig. 7. Structural analysis of CMP thioamide variants. ProSProGly and ProProGlyS have buried and partially buried sulfur atoms, respectively (Top and Middle), accounting for the disruptions observed in the CD experiments. The ProProSGly (Bottom) sulfur atom is fully solvent exposed and the N–H of the thioamide forms a hydrogen bond with the strand shown in grey (inset), accounting for the stabilization observed in the CD experiments. Structures rendered from PDB entry ; 2CUO. 67 .
