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. 2017 Mar 15;7:199. doi: 10.1038/s41598-017-00241-5

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Comparison of cellular migration after single and combined cell transplantation into subretinal space (SRS). (a–l) Vertical cellular migration of human retinal progenitor cells (HRPCs) and (or) human bone mesenchymal stem cells (HBMSCs) after single and combined cell transplantation to SRS on 3, 6, 9 and 12 post operational weeks. Results showed that vertical cellular migration started earlier in combined transplantation group. Also, more vertically migrated cells could be found in combined transplantation group. (m–o) Horizontal cellular migration of HRPCs and HBMSCs after single and combined cell transplantation to SRS on 6 post operational weeks. Results showed that more and broader horizontal cellular migration could be visualized in combined transplantation group. (p–q) Corresponding statistical analysis of (a–l). (r) Corresponding statistical analysis of (m,n). *P < 0.05; **P < 0.01; ***P < 0.001. (n = 3).