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. 2017 Mar 15;7:199. doi: 10.1038/s41598-017-00241-5

Figure 7.

Figure 7

Comparison of microglia activation after single and combined cell transplantation into subretinal space (SRS). (ad) Representative image of Iba1-staining microglia within grafted area after PBS, human retinal progenitor cells (HRPCs), human bone mesenchymal stem cells (HBMSCs) and combined cells injection on 3 post operational weeks. (eh) Representative image of Iba1-staining microglia within para-grafted area after PBS, HRPCs, HBMSCs and combined cells injection on 6 post operational weeks. (il) Representative image of Iba1-staining microglia within grafted area after PBS, HRPCs, HBMSCs and combined cells injection on 3 post operational weeks. (mp) Representative image of Iba1-staining microglia within para-grafted area after PBS, HRPCs, HBMSCs and combined cells injection on 6 post operational weeks. (q) Corresponding statistical analysis of (ap). GA: grafted area. PGA: Para-grafted area. (r) Western blot analysis of Iba1 protein on post operational 3 and 6 weeks (a’: PBS; b’: HRPCs; c’: HBMSCs; d’: HRPCs/HBMSCs). For original uncropped images, please see Supplementary Figs 2 and 3. (s) Corresponding statistical analysis of (r). *P < 0.05; **P < 0.01; ***P < 0.001. (n = 3).