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. 2017 Mar 14;7:177. doi: 10.1038/s41598-017-00263-z

Figure 6.

Figure 6

Normalised mitochondrial DNA copy number of cells expressing mitochondria-targeted M.SssI, the catalytically inactive double mutant of M.SssI, or M.CviPI. The effect of mitochondria-targeted M.SssI (MLS-M.SssI) or the catalytically inactive double mutant of M.SssI (MLS-M.SssI ∆∆, only for HCT116 cells) on mitochondrial DNA copy number normalised to empty vector control (MLS-NoED) was determined in stable cell lines of C33A (a) or HCT116 (b). Similarly, the effect of mitochondria-targeted M.CviPI (MLS-M.CvPI) on mitochondrial DNA copy number normalised to wild-type control (wt) was determined in stable cell lines of C33A (c) or HCT116 (d). Each data point represents the mean ± SEM of at least three independent experiments.