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. 2017 Mar 15;7:197. doi: 10.1038/s41598-017-00220-w

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© The Author(s) 2017

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Myeloid HO-1 dampens innate immune responses and oxidative stress upon renal IRI. LT (white bars) and HO-1^M-KO mice (grey bars) underwent sham surgery or 1 day of reperfusion after IRI. (A) Proinflammatory mediator levels in kidney. (B) Neutrophil and (D) macrophage influx counts. Representative renal sections stained for Ly6G (C) and F4/80 (E). Magnification, x400. Scale bar, 50 μm. (F) Percentage of nitrotyrosine-positive area in corticomedullary junction and (G) representative sections of nitrotyrosine immunostaining. Magnification, x400. Quantification for nitrotyrosine was done by using ImageJ software. Results are expressed as the mean ± SEM, ^★p < 0.05; ^★★p < 0.01; ^★★★p < 0.001. n = 7–9 for IRI groups and n = 5 for sham groups.