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. 2017 Mar 15;7:197. doi: 10.1038/s41598-017-00220-w

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Myeloid HO-1 promotes renal repair and attenuates interstitial fibrosis induced by renal IRI. (A) p53 mRNA, (B) p21 mRNA and (C) p62 renal expression in LT (white bars) and HO-1^M-KO (grey bars) mice subjected to sham surgery, 4 hours (p53 mRNA analysis) or 24 hours (p21 mRNA and p62 analysis) of reperfusion after renal IRI. Results are expressed as the mean ± SEM, ^★p < 0.05; ^★★p < 0.01. In p53/p21 experiments, n = 6–8 for IRI groups and n = 5–6 for sham groups. In p62 experiment, n = 9–10 for IRI groups and n = 6 for sham groups. (D) Percentage of fibrosis area and (E) representative renal sections of Masson Trichrome staining from sham-operated and IRI after 7 days of reperfusion in LT (white bars) and HO-1^M-KO (grey bars) mice. Quantification was done using ImageJ software. Results are expressed as the mean ± SEM, ^★★p < 0.01. n = 3–4 for IRI groups and n = 5 for sham groups. Magnification, x200.