Figure 2.

Gene expression and copy number of 64 oncogenes. (A) Gene expression levels of 12 oncogenes, including EGFR variant 1, ERBB2, MDM2, MYC, MYCL variants 1 and 2, MYCN, SKP2, NKX2-1, MET, HIST1H3B, EZH2, and CARD11, were linked to the genomic copy number. Pearson’s correlation coefficient (r with P-value) between copy number and mRNA expression is indicated at the bottom right. Red horizontal bars indicate 5-fold on the log₂ scale. (B) The relationship between gene overexpression and degree of genomic copy number gain. Tumors in which oncogenes were overexpressed by ≥5-fold were divided into three groups: those with high-level genomic amplification (copy number ≥6; dark blue bars), those with moderate genomic amplification (copy number 3–5; orange bars), and those without genomic amplification (copy number 1–2; light green bars). There were no cases with a copy number of zero among the indicated genes. Genes highlighted on the bottom correspond to the 12 oncogenes exhibited in panel A.