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. 2017 Apr 4;7:641. doi: 10.1038/s41598-017-00219-3

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Radar charts comparing the 12 core signaling pathways involved in amplified and overexpressed oncogenes in individual cancer types. Each axis of the diagrams represents a percentage of frequencies of pathway activation derived from amplified and overexpressed oncogenes, as listed in Table 2. As listed in Supplementary Table 1, 138 driver genes were assigned to the 12 signaling pathways, including APC, cell cycle/apoptosis (CC/A), chromatin modification (CM), DNA damage control (DDC), Hedgehog (HH), NOTCH, PI3K, RAS, receptor tyrosine kinase (RTK), STAT, TGF-β, and transcriptional regulation (TR).