Table 1.
HLA-cSCC Associations in Immunocompetent Patients
| HLA ALLELE | STUDY RESULTS
|
||||
|---|---|---|---|---|---|
| Population (Latitude) | No. of Cases | No. of Controls | Association (p-value) | Reference | |
| Class I HLA-cSCC Associations | |||||
|
| |||||
| B*58 | Italy (41.9°N) | 13 | 220 | negative (0.024) | [74] |
| Southern Australia (30.0°S) | 34 | 201 | null | [75] | |
|
| |||||
| Bw4a | United States (43.2°N) | 238 | 398 | negative (<0.001) | [76] |
|
| |||||
| Class II HLA-cSCC Associations | |||||
|
| |||||
| DRB1*01 | Italy (41.9°N) | 13 | 220 | positive (0.005) | [74] |
| United Kingdom (55.4°N) | 12 | 108 | nullb (0.09) | [6] | |
| Tropical Island, Saba (17°N) | 14 | 91 | null | [77] | |
|
| |||||
| DRB1*07 | Southern Australia (30.0°S) | 34 | 201 | positive (<0.01) | [75] |
|
| |||||
| DRB1*15 | United Kingdom (55.4°N) | 12 | 108 | nullc | [6] |
|
| |||||
| DRB1*16 | United Kingdom (55.4°N) | 12 | 108 | nullc | [6] |
|
| |||||
| DQB1 | United States (38.8°N) | 6579 | 280558 | positive (<10−5) | [12] |
|
| |||||
| DQA1 | United States (38.8°N) | 7701 | 60166 | positive (<5*10−8) | [13] |
Note: p-values for associations that were significant or borderline-significant at the α=0.05 level are reported
a
Bw4 is a serological epitope defined by amino acid residues at positions 77–83. All HLA-B alleles containing the Bw4 epitope are included here (including B*58).
b
Positive association with borderline significance at the α=0.05 level
c
Nonsignificant trend in favor of a negative association (α=0.05)