Table 3.
Enriched top 15 GO terms of DEGs between sepsis and normal samples
| GO ID | GO term | No. of genes | FDR |
|---|---|---|---|
| Biological process | |||
| GO:0006915 | Apoptotic process | 69 | 4.78E−14 |
| GO:0042981 | Regulation of apoptotic process | 33 | 8.32E−10 |
| GO:0015031 | Protein transport | 47 | 4.41E−09 |
| GO:0000278 | Mitotic cell cycle | 39 | 4.44E−09 |
| GO:0006355 | Regulation of transcription, DNA-dependent | 114 | 4.51E−09 |
| GO:0016192 | Vesicle-mediated transport | 30 | 6.59E−09 |
| GO:0007049 | Cell cycle | 47 | 1.16E−08 |
| GO:0000084 | S phase of mitotic cell cycle | 21 | 1.71E−07 |
| GO:0022904 | Respiratory electron transport chain | 18 | 3.59E−07 |
| GO:0006281 | DNA repair | 34 | 3.59E−07 |
| GO:0007596 | Blood coagulation | 45 | 3.80E−07 |
| GO:0045087 | Innate immune response | 35 | 6.18E−07 |
| GO:0006916 | Anti-apoptosis | 27 | 8.42E−07 |
| GO:0051301 | Cell division | 33 | 9.31E−07 |
| GO:0000075 | Cell cycle checkpoint | 21 | 1.73E−06 |
| Molecular function | |||
| GO:0005515 | Protein binding | 432 | 3.42E−86 |
| GO:0000166 | Nucleotide binding | 176 | 1.69E−22 |
| GO:0046872 | Metal ion binding | 207 | 2.45E−19 |
| GO:0005524 | ATP binding | 123 | 3.84E−15 |
| GO:0008270 | Zinc ion binding | 141 | 5.10E−13 |
| GO:0003677 | DNA binding | 128 | 2.45E−11 |
| GO:0016740 | Transferase activity | 62 | 8.39E−11 |
| GO:0016787 | Hydrolase activity | 77 | 1.87E−08 |
| GO:0003676 | Nucleic acid binding | 62 | 3.63E−06 |
| GO:0004672 | Protein kinase activity | 30 | 1.18E−05 |
| GO:0047485 | Protein N-terminus binding | 15 | 1.57E−05 |
| GO:0003723 | RNA binding | 50 | 1.58E−05 |
| GO:0042802 | Identical protein binding | 30 | 4.38E−05 |
| GO:0004197 | Cysteine-type endopeptidase activity | 12 | 5.98E−05 |
| GO:0016301 | Kinase activity | 25 | 6.31E−05 |
| Cellular component | |||
| GO:0005634 | Nucleus | 460 | 2.15E−73 |
| GO:0005737 | Cytoplasm | 450 | 3.48E−72 |
| GO:0005829 | Cytosol | 231 | 1.19E−49 |
| GO:0005739 | Mitochondrion | 141 | 2.64E−26 |
| GO:0016020 | Membrane | 278 | 2.14E−24 |
| GO:0005730 | Nucleolus | 139 | 1.82E−23 |
| GO:0005654 | Nucleoplasm | 102 | 6.78E−23 |
| GO:0005783 | Endoplasmic reticulum | 85 | 2.65E−11 |
| GO:0005886 | Plasma membrane | 209 | 1.03E−10 |
| GO:0005794 | Golgi apparatus | 81 | 1.12E−10 |
| GO:0005743 | Mitochondrial inner membrane | 37 | 9.65E−09 |
| GO:0048471 | Perinuclear region of cytoplasm | 44 | 1.28E−08 |
| GO:0005625 | Soluble fraction | 42 | 1.59E−08 |
| GO:0005694 | Chromosome | 33 | 2.80E−08 |
| GO:0005856 | Cytoskeleton | 66 | 1.99E−07 |