Table 4.
Enriched top 15 KEGG pathways of DEGs between sepsis and normal samples
| KEGG ID | KEGG term | Count | FDR | Genes |
|---|---|---|---|---|
| hsa00190 | Oxidative phosphorylation | 27 | 3.52E−11 | ATP5J, NDUFA2, COX17, COX6A1, ATP6V1D, COX5A, ATP6V0A1, COX6B1, COX5B, NDUFB11, ATP5J2, ATP6V0E1, ATP6V1E1, SDHB, TCIRG1, NDUFA4, COX8A, NDUFA13, COX7A2, COX7B, NDUFA1, ATP6V1E2, ATP6V0B, UQCR11, UQCRQ, ATP6V0D1, ATP5B |
| hsa00240 | Pyrimidine metabolism | 20 | 8.20E−09 | POLR2J, POLR2H, POLR1C, POLD2, POLR2L, NME4, AK3, TYMP, POLA1, NME7, NT5C2, POLD1, NME6, PRIM1, POLR3A, NME1, NT5E, CDA, NT5M, POLR3F |
| hsa04380 | Osteoclast differentiation | 23 | 8.54E−09 | TYROBP, MAPK3, MAPK13, IKBKG, SIRPA, NFKBIA, TNFRSF1A, SIRPB1, LILRB3, SYK, CYBA, FCGR2A, IFNGR1, LILRA2, SPI1, NCF4, LILRB2, NCF2, IFNAR2, JUNB, PIK3CG, LILRA6, PPARG |
| hsa05016 | Huntington’s disease | 28 | 9.50E−09 | POLR2J, ATP5J, POLR2H, NDUFA2, AP2S1, COX6A1, POLR2L, COX5A, COX6B1, COX5B, NDUFB11, CASP9, SDHB, NDUFA4, COX8A, CLTCL1, SOD2, NDUFA13, COX7A2, HIP1, COX7B, NDUFA1, DNAL4, UQCR11, PPARG, UQCRQ, TBPL1, ATP5B |
| hsa05010 | Alzheimer’s disease | 26 | 1.01E−08 | ATP5J, MAPK3, NDUFA2, COX6A1, TNFRSF1A, FAS, COX5A, COX6B1, COX5B, PSENEN, NDUFB11, CASP9, PPP3R1, NAE1, SDHB, NDUFA4, COX8A, GRIN2A, NDUFA13, COX7A2, COX7B, NDUFA1, UQCR11, UQCRQ, ATP5B, PSEN1 |
| hsa05130 | Pathogenic Escherichia coli infection | 14 | 1.61E−07 | CDC42, ARPC2, ARPC4, ABL1, YWHAZ, YWHAQ, RHOA, LY96, TUBA1B, CD14, ARPC3, TUBA1C, TUBA1A, TUBA4A |
| hsa04145 | Phagosome | 22 | 1.74E−07 | CTSS, TLR2, ATP6V1D, ATP6V0A1, PIK3C3, ATP6V0E1, ATP6V1E1, CYBA, FCGR2A, TCIRG1, TUBA1B, CD14, RAB5A, NCF4, NCF2, ATP6V1E2, ATP6V0B, VAMP3, ATP6V0D1, TUBA1C, TUBA1A, TUBA4A |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 15 | 3.57E−07 | CDC42, MAPK13, IKBKG, NFKBIA, ATP6V1D, ATP6V0A1, CXCL1, ATP6V0E1, ATP6V1E1, CXCR1, LYN, TCIRG1, ATP6V1E2, ATP6V0B, ATP6V0D1 |
| hsa04666 | Fc gamma R-mediated phagocytosis | 17 | 7.49E−07 | CDC42, ARPC2, VAV1, MAPK3, ARPC4, PRKCD, RAC2, DNM2, SYK, GSN, FCGR2A, LYN, PTPRC, ARPC3, PIK3CG, HCK, LIMK2 |
| hsa05012 | Parkinson’s disease | 20 | 9.47E−07 | ATP5J, NDUFA2, COX6A1, COX5A, COX6B1, COX5B, NDUFB11, CASP9, SDHB, NDUFA4, COX8A, NDUFA13, COX7A2, COX7B, NDUFA1, HTRA2, UQCR11, PINK1, UQCRQ, ATP5B |
| hsa05152 | Tuberculosis | 23 | 1.48E−06 | MAPK3, CTSS, MAPK13, ITGAX, TLR2, NFYA, IL10RB, TNFRSF1A, ATP6V0A1, RHOA, SYK, PIK3C3, CASP9, RFXANK, PPP3R1, FCGR2A, TCIRG1, IFNGR1, CD14, RAB5A, ATP6V0B, CEBPB, ATP6V0D1 |
| hsa00230 | Purine metabolism | 21 | 5.46E−06 | POLR2J, POLR2H, POLR1C, POLD2, AK1, POLR2L, NME4, IMPDH1, POLA1, NME7, NT5C2, POLD1, NME6, PFAS, PRIM1, POLR3A, AMPD3, NME1, NT5E, NT5M, POLR3F |
| hsa04110 | Cell cycle | 18 | 8.22E−06 | MDM2, ABL1, YWHAZ, FZR1, PTTG1, CDC7, YWHAQ, ANAPC4, ORC2, SKP1, CDC16, CDKN2D, ANAPC11, ZBTB17, RBL1, CCND3, MAD1L1, E2F4 |
| hsa04621 | NOD-like receptor signaling pathway | 12 | 1.16E−05 | TAB3, MAPK3, CASP5, MAPK13, IKBKG, BIRC2, CASP1, NFKBIA, CXCL1, BIRC3, PYCARD, PSTPIP1 |
| hsa04062 | Chemokine signaling pathway | 22 | 1.75E−05 | CDC42, VAV1, MAPK3, IKBKG, PTK2B, PRKCD, GRK6, RAC2, NFKBIA, GNB4, CXCL1, RHOA, ARRB2, GNG10, CXCR1, LYN, CCR1, GNB2, PIK3CG, HCK, FGR, CCR6 |