Fig. 7.
SS-14 and SOM230 induce distinct patterns of ß-arrestin trafficking. HEK293 cells were transiently transfected with 2 μg of ß-arrestin-2-EGFP, 6 μg of sst2A, and 4 μg of GRK2 or 4 μg empty vector. The distribution of ß-arrestin-2 was visualized sequentially in the same live cells before (0 min) and after (1, 5, 15, and 30 min) the addition of either 1 μm SS-14 or 10 μm SOM230 to the culture medium. Shown are representative images from one of four independent experiments performed in duplicate. Scale bar, 20 μm.