Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Jan;24(1):261–274. doi: 10.1210/me.2009-0473

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

PMC Copyright notice

Fig. 13. — NK_B and GnIH: novel regulators of gonadotropin in man. Schematic describing the potential mechanisms for control of gonadotropin secretion by NK_B and GnIH. Kisspeptin (Kiss) released from kisspeptin neurons within the hypothalamus is known to control secretion of GnRH from GnRH neurons through interaction with its cognate receptor (KissR/GPR54). Secretion of GnRH from these neurons then leads to secretion of gonadotropins (LH/FSH) from pituitary gonadotropes. NK_B is colocalized in kisspeptin neurons and is postulated to be a novel regulator of GnRH secretion either through direct interaction with GnRH neurons or through autocrine interactions with kisspeptin neurons. GnIH is a potent inhibitor of GnRH stimulation of gonadotropin secretion from cultured gonadotropes but may also operate by inhibiting the activity of GnRH neurons.