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GPR119-dependent insulinotropic effect of OLDA and OEA. RIN-5F cells were stably transfected with human GPR119 expression plasmid (RIN-5F/hGPR119) or with empty plasmid (RIN-5F/vector). Cells were treated with the indicated concentrations of OLDA or OEA and subsequently evaluated for cAMP production (A) or insulin release (B). C, LPC-stimulated insulin release in both vector-transfected and GPR119-expressing RIN-5F stables.
