Fig. 5.

OLDA improves oral glucose tolerance in mice in a GPR119-dependent manner. Overnight-fasted male mice were dosed with either vehicle or 100 mg/kg OLDA via oral gavage. An oral glucose bolus (3 g/kg) was then administered 30 min after vehicle or OLDA treatment. Plasma glucose levels (mg/dl) were determined using a OneTouch Ultra Glucose meter and blood (∼5 μl) collected from tail nick at indicated time points (time in minutes relative to glucose bolus). Glucose excursion curve was shown for wild-type littermates (A) and for GPR119-deficient mice (B) and from data collected from six (n = 6) in each treatment group and genotype (mean ± sem, n = 6). C, The area under the curve (AUC) of the glucose excursion curve from time 0 to 120 min after glucose bolus was shown for each treatment group, as indicated. Statistical significance (P value) was assessed by t test between vehicle-treated and OLDA treated-groups. KO, Knockout; PO, per oral; WT, wild type; n.s., not significant.