Table 1.
Blood and urinary parameters in wild type and ERRα null mice
| WT | ERRα KO | P Value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | sem | Mean | sem | ||||||
| Body weight (g) | 24.5 | 0.3 | 22.2 | 0.6 | 0.002 | ||||
| Water intake (ml) | 4.6 | 0.7 | 3.4 | 0.1 | 0.100 | ||||
| Urine volume (ml) | 1.07 | 0.12 | 0.54 | 0.12 | 0.008 | ||||
| GFR (ml/d) | 1.00 | 0.11 | 0.75 | 0.12 | 0.129 | ||||
| Urinary parameters (mmol/d) | |||||||||
| Creatinine | 4.0 | 0.3 | 2.4 | 0.4 | 0.025 | ||||
| Na+ | 166.7 | 24.4 | 94.6 | 14.5 | 0.035 | ||||
| K+ | 323.5 | 38.3 | 206.1 | 40.6 | 0.069 | ||||
| Na/K ratio | 0.51 | 0.04 | 0.49 | 0.05 | 0.816 | ||||
| Chloride | 270.1 | 46.2 | 160.8 | 28.6 | 0.097 | ||||
| Ca2+ | 2.1 | 0.5 | 1.9 | 0.5 | 0.971 | ||||
| Blood parameters | |||||||||
| Urea | 8.32 | 0.53 | 8.23 | 0.30 | 0.885 | ||||
| Creatinine | 18.21 | 1.87 | 17.40 | 1.95 | 0.760 | ||||
| Na+ | 140.79 | 0.90 | 144.80 | 1.00 | 0.005 | ||||
| K+ | 8.29 | 0.21 | 6.73 | 0.15 | <0.001 | ||||
| Na+/K+ ratio | 16.04 | 0.65 | 20.30 | 0.62 | <0.001 | ||||
| Chloride | 107.95 | 0.63 | 108.60 | 0.63 | 0.455 | ||||
| Ca2+ | 2.17 | 0.07 | 2.22 | 0.03 | 0.462 | ||||
Values are presented as mean ± sem Unpaired Student t test was used for statistical analysis. Measurements were made at ZT4 on five metabolic cages each housing three to five mice per cage. A total of 19 mice per genotype were used for the analysis. GFR, Glomerular filtration rate; KO, knockout; WT, wild type.