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. 2017 Mar 21;7:263. doi: 10.1038/s41598-017-00364-9

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Amino acid changes in CD4⁺ and CD8⁺ specific T cell epitopes of HPV16 E6 and E7 proteins. Amino acid changes in at least one of the 51 HPV16 isolates at CD4⁺ and CD8⁺ specific T cell epitopes are marked with hollow and solid arrows, respectively. Stacking arrows indicate that the amino acid change is in a peptide which serves as both CD4⁺ and CD8⁺ epitopes.