Table 2.
Number of malformed or non-malformed embryos at 10.5 days of gestation during non-diabetic or diabetic pregnancies.
| Genotype | Diabetic mother | Number of embryos examined | Number of non-malformed embryos | Number of embryos with craniofacial malformations | Number of embryos with caudal malformations | Total percentage of malformed embryos |
|---|---|---|---|---|---|---|
| Alx3 +/+ | No | 132 | 132 | 0 (0) | 0 (0) | 0 |
| Alx3 +/− | No | 192 | 188 | 4 (2.08) | 0 (0) | 2.08 |
| Alx3 −/− | No | 86 | 82 | 4 (4.65) | 0 (0) | 4.65 |
| Alx3 +/+ | Yes | 78 | 74 | 0 (0) | 4 (5.12) | 5.12 |
| Alx3 +/− | Yes | 171 | 147 | 13 (7.6)a,d | 11 (6.43) | 14.03f |
| Alx3 −/− | Yes | 152 | 115 | 24 (15.78)b,c,e | 13 (8.55) | 24.34g |
Numbers in parenthesis denote percentage of total.
a p < 0.05 relative to Alx3 +/− embryos from non-diabetic mothers; Fisher’s exact test.
b p < 0.05 relative to Alx3 +/− embryos from diabetic mothers; Fisher’s exact test.
c p < 0.05 relative to Alx3 −/− embryos from non-diabetic mothers; Fisher’s exact test.
d,f p < 0.001 relative to Alx3 +/− embryos from non-diabetic mothers plus Alx3 +/+ embryos from diabetic mothers; χ2 test.
e,g p < 0.001 relative to Alx3 −/− embryos from non-diabetic mothers plus Alx3 +/+ embryos from diabetic mothers; χ2 test.