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. 2017 Mar 15;7:191. doi: 10.1038/s41598-017-00301-w

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MKL1 deficiency cripples inflammatory response in mice. (A) C57/BL6 mice were injected with LPS (25 mg/kg). Peritoneal macrophages were isolated 6 hours after injection and ChIP assays were performed with anti-MKL1. (B,C) Sex- and age-matched WT and MKL1 KO male mice were injected with LPS (25 mg/kg). Survival (B) and body temperature (C) were monitored following injection. N = 10 mice for each group. (D–G) Mice were sacrificed 4 hours after injection. Circulating levels of pro-inflammatory mediators were measured by ELISA. N = 6 mice for each group.