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. 2017 Mar 21;7:248. doi: 10.1038/s41598-017-00344-z

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© The Author(s) 2017

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Tomosyn and secretagogin interaction decreases in response to insulin secretagogues. (a) Pull-down of GFP-tomosyn1 demonstrates an interaction with secretagogin (Scgn) in INS 832/13 cells (representative of n = 4). (b) Pull-down of native tomosyn demonstrates an interaction with secretagogin in human islets (representative of n = 3). (c) Stimulation with 10 mM glucose and 30 mM KCl for 15 minutes reduces the tomosyn and secretagogin interaction (representative of n = 3). (d) Secretagogin is expressed in ß- and α-cells as shown by immunostaining of human pancreatic sections for secretagogin (red) and insulin (green, top) or glucagon (green, bottom) (representative of pancreatic section from 6 human donors). *Unspecific bands.