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TTR binding sites in the presence of tolcapone and mds84. Wild type TTR binding sites occupied by tolcapone (A) and mds84 (B) with ligands shown as solvent accessible surfaces. For clarity, H2O oxygens are shown as spheres with 50% of the van der Waals radius. (C) Wild type TTR-mds84 complex with highlighted distances of the principal hydrophobic contacts between the ligand methylene linker and TTR atoms.
