Table 1.
Effect of pNaKtide on body weight; visceral fat, subcutaneous fat and liver weight; energy expenditure; locomotor activity and oxygen consumption in C57Bl/6 and ApoE−/− mice fed a western diet.
| C57Bl6 | ApoE−/− | |||||
|---|---|---|---|---|---|---|
| CTR | WD | WD + pNaKtide | CTR | WD | WD + pNaKtide | |
| BW (g, Baseline) | 22.5 ± 0.7 | 21.4 ± 0.4 | 20.1 ± 0.7 | 20.6 ± 0.4 | 20.7 ± 0.6 | 21.2 ± 0.6 |
| BW (g, 4 week) | 24.7 ± 1.08 | 25.6 ± 0.7 | 24.9 ± 0.9 | 24.4 ± 0.6 | 25.8 ± 0.7 | 26.9 ± 1.04 |
| BW (g, 12 week) | 28.2 ± 1.1 | 40.7 ± 0.8** | 32.9 ± 0.9**,## | 28.5 ± 1.04 | 29.9 ± 1.06 | 30.4 ± 1.5 |
| Visceral fat (g) | 0.5 ± 0.05 | 3.1 ± 0.1** | 1.9 ± 0.1**,## | 0.5 ± 0.02 | 0.5 ± 0.06 | 0.5 ± 0.02 |
| SC Fat (g) | 0.4 ± 0.03 | 1.9 ± 0.1** | 0.9 ± 0.06**,## | 0.3 ± 0.02 | 0.3 ± 0.02 | 0.3 ± 0.02 |
| Liver weight (g) | 1.8 ± 0.04 | 2.7 ± 0.2** | 1.8 ± 0.08## | 1.7 ± 0.07 | 1.7 ± 0.04 | 1.7 ± 0.03 |
| Energy expenditure (kcal/kg/hr) | 15.2 ± 0.3 | 12.6 ± 0.6* | 15.1 ± 0.6# | 18.8 ± 0.4 | 16.1 ± 0.3** | 18.06 ± 0.4# |
| Locomotor Activity (Ambulatory count/24 hours) | 19565.2 ± 2188.2 | 11702 ± 660.05** | 24438.1 ± 2678.4# | 23670.5 ± 1500.6 | 18757 ± 483.4* | 26301.8 ± 1603.3# |
| Oxygen consumption (ml/kg/hr) | 3083.01 ± 72.1 | 2622.05 ± 138.5* | 3155 ± 129.06# | 3799.7 ± 75.3 | 3342.2 ± 93.9* | 3704.5 ± 82.5# |
Results are means ± SEM, n = 6/group. *p < 0.05, **p < 0.01 vs. control; #<0.05, ##p < 0.01 vs WD.