Table 4.

Effect of pNaKtide on metabolic profile in plasma of C57Bl6 and ApoE−/− mice fed a western diet.

	C57Bl6			ApoE−/−
	CTR	WD	WD + pNaKtide	CTR	WD	WD + pNaKtide
HOMA-IR	0.8 ± 0.08	2.5 ± 0.3**	1.09 ± 0.03##	1.3 ± 0.06	5.6 ± 0.4**	2.1 ± 0.1##
ALT (U/L)	3.5 ± 0.9	7.9 ± 0.6**	4.9 ± 0.4#	3.3 ± 0.6	6.9 ± 0.8**	4.2 ± 0.5#
Triglycerides (mg/dl)	24.3 ± 1.7	39.8 ± 4.8**	26.8 ± 1.6#	94.02 ± 4.2	147.6 ± 3.1**	116 ± 9.05##
FFA (mmol/l)	0.2 ± 0.02	0.9 ± 0.07**	0.6 ± 0.06*,#	0.4 ± 0.04	1.03 ± 0.08**	0.6 ± 0.08#
LDL (mg/dl)	10.2 ± 0.7	42.6 ± 3.1**	23.5 ± 3.1**,##	101.4 ± 4.9	239.5 ± 16.2**	158.3 ± 7.3**,##
HDL (mg/dl)	48.4 ± 0.7	14.5 ± 1.03**	45.7 ± 2.9##	32.9 ± 2.01	8.1 ± 2.6**	28.3 ± 3.2##
ROS (mmol)	1.01 ± 0.1	4.6 ± 0.7**	1.5 ± 0.3##	1.4 ± 0.4	6.6 ± 0.06**	3.3 ± 0.6##

Results are means ± SEM, n = 6/group. *p < 0.05, **p < 0.01 vs. control; ^#<0.05, ^##p < 0.01 vs WD.