Table 4.

Adjusted associations for methylation levels of the 9-CpGs in the DMR of the PON1 gene in cord-blood of males with cognitive test scores measured during early childhood. Estimated change in cognitive test scores per 10% increase in methylation of each CpG and mean methylation levels of the PON1 region.

PON1 CpG ID	PPVT score (N = 135)		WRAVMA total (N = 128)
Cord Blood Methylation	β-Coefficient (95% CI)	P	β-Coefficient (95% CI)	P
cg07404485	−2.1 (−3.7, −0.2)	0.19	0.03 (−2.2, 2.2)	0.97
cg05342682	−3.2 (−6.2, −0.2)	0.03	−1.5 (−3.7, 0.6)	0.15
cg04155289	−0.5 (−2.9, 4.0)	0.75	−0.4 (−2.8, 1.9)	0.72
cg19678392	−2.2 (−4.6, 0.2)	0.07	−0.4 (−2.1, 1.3)	0.64
cg21856205	−4.4 (−8.7, −0.1)	0.04	−1.1 (−4.2, 2.0)	0.48
cg17330251	−1.9 (−3.6, −0.1)	0.03	−0.3 (−1.5, 0.9)	0.64
cg01874867	−2.0 (−3.7, −0.2)	0.02	−0.4 (−1.7, 0.8)	0.48
cg20119798	−2.1 (−5.0, 0.7)	0.13	−0.5 (−2.4, 1.5)	0.64
cg04871131	−2.9 (−9.0, 3.2)	0.35	−1.1 (−5.3, 3.2)	0.62
Mean DMR methylation	−2.6 (−5.6, 0.3)	0.07	−0.6 (−2.7, 1.4)	0.55

(PPVT = Peabody Picture Vocabulary Test; WRAVMA = Wide Range Assessment of Visual Motor Abilities).