Table 11.
Hexonate and hexuronate utilization and carbohydrate metabolism.
| Gene | Function | Fold change | ||
|---|---|---|---|---|
| 7 min | 25 min | 45 min | ||
| GLYCOLYSIS/HEXOSE METABOLISM | ||||
| fbaB | Fructose-bisphosphate aldolase | 2.27 | 2.98 | 4.28 |
| frwB | Putative fructose-like phosphotransferase EIIB subunit 2 | 2.28 | 2.52 | 2.56 |
| frwC | Putative fructose-like permease EIIC subunit 2 | 1.59 | 2.35 | 2.17 |
| gapA | Glyceraldehyde 3-phosphate dehydrogenase A | 3.10 | 2.33 | 2.02 |
| gpmA | Phosphoglycerate mutase 1 | 1.48 | 1.94 | 2.14 |
| pfkB | 6-phosphofructokinase 2 | 4.53 | 5.47 | 4.87 |
| ptsA (frwA) | Phosphoenolpyruvate-protein phosphotransferase | 1.69 | 2.26 | 2.53 |
| ptsH | Phosphohistidinoprotein-hexose phosphotransferase component of PTS system (HPr) | 1.76 | 2.07 | 2.28 |
| pykA | Pyruvate kinase | n.s. | 1.73 | 1.99 |
| talC | Fructose-6-phosphate aldolase | 2.88 | 5.38 | 5.62 |
| treB | Trehalose(maltose)-specific PTS system components IIBC | 2.52 | 2.49 | 2.27 |
| ONE CARBON PATHWAY | ||||
| gcvA | DNA-binding transcriptional activator GcvA | n.s. | 0.62 | 0.39 |
| gcvH | Glycine cleavage system protein H | 1.94 | 2.00 | 2.15 |
| gcvT | Glycine cleavage system aminomethyltransferase T | 2.13 | 2.08 | 2.12 |
| kbl | 2-amino-3-ketobutyrate coenzyme A ligase | 2.65 | 2.20 | 2.00 |
| tdh | L-threonine 3-dehydrogenase | 2.23 | 1.80 | 1.64 |
| glyA | Serine hydroxymethyltransferase | 3.40 | 2.83 | 2.56 |
| sdaA | L-serine deaminase 1 | 3.03 | 3.54 | 3.34 |
| serB | Phosphoserine phosphatase | 2.85 | 2.40 | 2.75 |
| TCA CYCLE | ||||
| aceE | Pyruvate dehydrogenase subunit E1 | 0.21 | 0.36 | 0.36 |
| aceF | Dihydrolipoamide acetyltransferase | 0.23 | 0.44 | 0.43 |
| acnA | Aconitate hydratase | 0.45 | 0.51 | 0.37 |
| acnB | Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase | 0.29 | 0.35 | 0.27 |
| lpdA | Dihydrolipoamide dehydrogenase | 0.30 | 0.50 | 0.48 |
| MIXED FERMENTATION | ||||
| ackA | Acetate kinase | n.s. | 2.02 | 2.23 |
| adhP | Alcohol dehydrogenase | n.s. | 2.22 | 1.95 |
| PENTOSE PHOSPHATE SHUNT (NON-OXIDATIVE BRANCH) | ||||
| rpiA | Ribose-5-phosphate isomerase A | 3.01 | 2.24 | 2.15 |
| tktA | Transketolase | 2.94 | 2.91 | 3.17 |
| D-GALACTONATE UTILIZATION | ||||
| dgoA | D-galactonate dehydratase (SEN3644) | 5.87 | 26.22 | 24.85 |
| dgoD | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase (SEN3645) | 6.67 | 23.93 | 22.03 |
| dgoK | 2-dehydro-3-deoxygalactonokinase | 9.47 | 34.35 | 31.13 |
| dgoR | Galactonate operon transcriptional repressor | 8.96 | 28.70 | 27.13 |
| dgoT | D-galactonate transporter | n.s. | 10.77 | 13.59 |
| dkgB | 2,5-diketo-D-gluconate reductase B | 2.89 | 2.19 | 2.85 |
| yiaE | Putative 2-hydroxyacid dehydrogenase | 2.05 | 2.04 | 2.07 |
| MANNONATE UTILIZATION | ||||
| SEN2978 | Mannonate dehydratase (uxuA) | 4.39 | 24.16 | 28.19 |
| SEN2979 | D-mannonate oxidoreductase (uxuB) | n.s. | 16.77 | 19.11 |
| SEN2980 | Glucuronate isomerase; uronate isomerase; uronic isomerase (uxaC) | n.s. | 8.81 | 10.68 |
| HEXONATE UTILIZATION | ||||
| eda | Keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase | 2.09 | 2.01 | 1.94 |
| SEN1433 | L-idonate 5-dehydrogenase IdnD | 3.05 | 3.21 | 5.17 |
| SEN1434 | Hexonate sugar transporter | n.s. | 2.70 | 5.68 |
| SEN1435 | Gluconate 5-dehydrogenase | n.s. | 3.07 | .40 |
| SEN1436 | D-galactonate dehydratase family member SEN1436 | n.s. | 10.30 | 33.38 |
Highlighted fold changes correspond to up-regulated (dark gray) and down-regulated (light gray) genes. (n.s.), fold changes with p > 0.05.