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. 2017 Mar 3;7:45. doi: 10.1038/s41598-017-00079-x

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© The Author(s) 2017

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Expression and regulation of CDKIs and other cell cycling-related genes. Except for CDKN2B, transcriptional analyses showed that all other tested CDKI genes and the tumor suppressor RB1 were underexpressed in UM and MetMU as compared to NUM; and all the CDKI genes, except for CDKN1B, were downregulated in C918 than in OCM1. (A) CDKN1A. (B) CDKN1B. (C) CDKN1C. (D) CDKN2A. (E) CDKN2B. (F) CDKN2C. (G) CDKN2D. (H) RB1. Knockdown of ZEB1 significantly magnified (I) CDKN1A and (J) CDKN2A expression in both OCM1 and C918. Some G-protein-related signaling elements such as (K) BRAF and (L) GNA11 were transcriptionally upregulated in UM and MetUM, but not (M) GNAQ. (N) ChIP assays showed that ZEB1 bound the promoter of CDKN1A. Mean (M) ± standard deviation (SD). ‘**’ Indicates Student’s t-test p ≤ 0.01.