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. 2017 Mar 6;7:72. doi: 10.1038/s41598-017-00067-1

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© The Author(s) 2017

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Rv2170 acetylates Mtb ICDH1 (Rv3339c) at K30 and K129. (A) Protein sequence of ICDH1. six lysine residues in both Mtb ICDH1 and human mitochondrial ICDH known to be acetylated are shown in red are conserved⁴⁵. The two acetylated lysine residues in Mtb ICDH1 detected in our study are marked with asterisk. Substrate binding regions for isocitrate and NADP⁺ are highlighted with dot and purple respectively. (B and C) modified sites of ICDH1 by Rv2170 were identified by mass spectrometry analysis. The MS/MS spectrum of acetylated peptides LIKDMLILPYLDIR and LVPGWTKPIVIGR of ICDH1 were shown and the observed fragment ions (b and y ions) are marked on the spectrum and also summarized schematically. These peptides are underlined on the protein sequence (A).