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. 2017 Mar 6;7:72. doi: 10.1038/s41598-017-00067-1

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© The Author(s) 2017

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ICDH1 activity is repressed through acetylation by Rv2170. (A and B) ICHD1 activity was measured by quantifying NADPH generation during incubation in the presence or absence of Rv2170 and acetyl-CoA. ICDH1 activity was inhibited by Rv2170 only in the presence of acetyl-CoA. (C and D) Graphs show substrate saturation curves for lysine acetylation by Rv2170 (C) as the ICDH1 substrate is varied at a saturating concentration of acetyl-CoA(200 μM) or (D) as the acetyl-CoA substrate is varied at a saturating concentration of ICDH1 (10 μg) Error bars show standard deviations from three representative triplicate.