Table 3.

Result of two-distribution perturbation analysis for apoptosis or hypertrophy.

Pair of perturbed parameter distributions	1 million parameter sets		10 million parameter sets		100 million parameter sets
	Synergistic effect	p-value	Synergistic effect	p-value	Synergistic effect	p-value
Apoptosis
pm1-pm10	0.078	0.012	0.082	0.012	0.076	0.018
pm2-pm10	0.15	0.009	0.132	0.009	0.139	0.009
pm3-pm10	0.155	0.002	0.17	0.002	0.156	0.004
pm6-pm10	0.161	0.004	0.167	0.002	0.17	0.005
pm7-pm10	0.528	<0.001	0.514	<0.001	0.527	<0.001
pm7-pm30	0.086	0.015	0.085	0.015	0.091	0.012
pm8-pm10	0.102	0.008	0.099	0.01	0.089	0.014
pm9-pm10	0.089	0.017	0.088	0.013	0.1	0.016
pm10-pm11	0.096	0.014	0.106	0.007	0.107	0.007
pm10-pm13	0.08	0.016	0.086	0.018	0.093	0.013
pm10-pm14	0.081	0.018	0.08	0.014	0.069	0.03
pm10-pm15	0.067	0.03	0.063	0.028	0.065	0.040
pm10-pm17	0.092	0.014	0.087	0.019	0.079	0.011
pm10-pm19	0.083	0.013	0.082	0.017	0.085	0.011
pm10-pm20	0.107	0.009	0.108	0.008	0.115	0.005
pm10-pm26	0.104	0.009	0.099	0.018	0.105	0.008
pm10-pm30	0.076	0.013	0.119	0.008	0.094	0.018
pm10-pm32	0.074	0.017	0.085	0.011	0.08	0.02
pm10-pm33	0.079	0.017	0.089	0.015	0.074	0.015
pm10-pm34	0.108	0.009	0.108	0.01	0.096	0.011
pm10-pm35	0.089	0.019	0.084	0.01	0.085	0.016
pm10-pm36	0.096	0.013	0.083	0.016	0.098	0.012
pm10-pm37	0.1	0.008	0.1	0.02	0.086	0.019
pm22-pm23	0.145	0.009	0.138	0.008	0.143	0.009
Hypertrophy
pm7-pm10	0.354	<0.001	0.355	<0.001	0.359	<0.001
pm7-pm13	0.132	0.007	0.134	0.01	0.137	0.006
pm7-pm14	0.169	0.003	0.166	0.002	0.172	0.002
pm7-pm21	0.414	<0.001	0.418	<0.001	0.417	<0.001
pm10-pm14	0.124	0.008	0.115	0.008	0.131	0.007
pm16-pm17	0.155	0.002	0.149	0.006	0.143	0.007

Results of two-distribution perturbation analysis for apoptosis and hypertrophy. The synergistic effect was calculated as the difference between the effect of simultaneous perturbation of marginal distributions of two parameters on the phenotype and the sum of that obtained from perturbing either individual marginal distribution. The data represent average synergistic effect of simulation analysis using each response function separately. Higher values indicate stronger synergistic effect. Parameter pairs exhibiting synergistic effect for apoptosis or hypertrophy with significance (p < 0.05) are shown. The mathematical analysis was all repeated for 10 times using different random seeds of 1, 10, or 100 million parameter sets for each case. p-values were determined using Student’s t test. See Supplementary Data Sets for full data.