Table 3.

Multivariate Cox proportional hazard ratio of mortality in which PTH, ALP, calcium and phosphorus were considered as categorical variables.

	Baseline			Time-dependent
	HR	95% CI	p value	HR	95% CI	p value
Age (per 10 year increments)	1.21	1.08~1.34	0.0007	1.13	1.10~1.16	<0.0001
Male	1.05	0.77~1.43	0.7498	1.11	1.02~1.20	0.0153
DM	1.06	0.78~1.45	0.6964	1.02	0.94~1.11	0.6073
Kt/V (per 1 increment)	0.52	0.33~0.83	0.0061	0.68	0.61~0.75	<0.0001
Albumin (per g/dL increment)	0.56	0.39~0.82	0.0028	0.31	0.29~0.34	<0.0001
Hb (per g/dL increment)	0.89	0.78~1.01	0.0809	1	0.98~1.03	0.8929
Ca (mg/dL)
<8.5	1.25	0.88~1.79	0.2148	1.06	0.95~1.18	0.2962
8.5~9.5	Ref	—	—	Ref	—	—
9.5~10.5	1.52	1.02~2.27	0.0276	1.11	1.01~1.22	0.0353
≧10.5	1.38	0.43~4.44	0.8687	1.36	1.18~1.56	<0.0001
P (mg/dL)
<3.5	1.74	1.09~2.27	0.0198	1.21	1.09~1.35	0.0005
3.5~5.5	Ref.	—	—	Ref	—	—
5.5~6.5	0.83	0.53~1.31	0.4333	0.98	0.87~1.09	0.6490
6.5~7.5	1.08	0.53~2.22	0.8261	1.19	1.04~1.37	0.0127
7.5~8.5	1.49	0.53~4.20	0.4461	1.47	1.22~1.77	<0.0001
≧8.5	2.85	0.67~12.09	0.1551	1.43	1.10~1.86	0.0079
PTH (pg/mL)
<50	0.96	0.55~1.66	0.8834	1.11	0.98~1.24	0.0985
50~150	1.10	0.75~1.63	0.6225	1.04	0.93~1.16	0.4726
150~300	Ref.	—	—	Ref	—	—
300~600	0.87	0.58~1.31	0.5130	0.90	0.80~1.01	0.0806
≧600	1.01	0.54~1.89	0.9832	0.86	0.74~0.99	0.0377
ALP (IU/L)
<50	1.04	0.52~2.09	0.9216	0.87	0.73~1.03	0.1072
50~100	Ref	—	—	Ref	—	—
100~150	1.26	0.87~1.83	0.2185	1.28	1.15~1.41	<0.0001
≧150	1.61	1.12~2.31	0.0100	1.57	1.43~1.72	<0.0001
Renal CCr (per mL/min increment)†	1.13	1.06~1.19	<0.0001	—	—	—

PTH, parathyroid hormone; ALP, total alkaline phosphatase; HR, hazard ratio; CI, confidence interval; DM, diabetes mellitus; Kt/V, weekly Kt/V; Hb, hemoglobin, Ca, total calcium; P, phosphorus; renal CCr, renal creatinine clearance.

^†Renal creatinine clearance was not included in the time-dependent analysis due to large number of missing baseline values (n = 1879).