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. 2017 Mar 30;15(5):2983–2990. doi: 10.3892/mmr.2017.6416

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — ERY has a protective role in the disturbance of MMP and anti-MMP activity in CS-induced emphysema in rats. (A) The protein expression of MMP-2, MMP-9 and TIMP-1 as measured by immunohistochemical staining (original magnification, ×400). (B) Protein expression levels of MMP-2, MMP-9 and TIMP-1 as measured by western blotting, with quantification relative to β-actin. For TIMP-1, the upper band was considered to be non-specific binding. Data are presented normalized to the control and are the mean ± standard deviation. Control rats were exposed to normal air and received daily saline injections. CS rats were exposed to CS for 12 weeks. CS + ERY rats were exposed to CS for 12 weeks and received daily injections of 100 mg/kg ERY. *P<0.05 vs. control group and ^#P<0.05 vs. CS group; n=12 per group. CS, cigarette smoke; ERY, erythromycin; MMP, metalloprotease; TIMP-1, tissue inhibitor of metalloproteinases.