Table 1.

Effect of smoking reduced nicotine content cigarette on weight gain (kg) over six weeks.

Treatment Group	Week 1	Week 2	Week 3	Week 4	Week 5	Week 6
15.8 mg group as reference group (primary analysis):
5.2 mg/g	0 (−0.48, 0.48)	0.29 (−0.2, 0.77)	0.01 (−0.47, 0.5)	0.13 (−0.36, 0.62)	0.14 (−0.36, 0.63)	0.01 (−0.48, 0.49)
2.4 mg/g	0.01 (−0.47, 0.5)	0.34 (−0.15, 0.83)	0.08 (−0.41, 0.58)	0.24 (−0.26, 0.73)	0.37 (−0.13, 0.87)	0.22 (−0.27, 0.71)
1.3 mg/g	0.2 (−0.28, 0.68)	0.52 (0.03, 1)	0.25 (−0.24, 0.73)	0.16 (−0.34, 0.65)	0.22 (−0.27, 0.71)	0.18 (−0.3, 0.67)
0.4 mg/g	0.1 (−0.39, 0.59)	0.36 (−0.13, 0.85)	0.11 (−0.39, 0.6)	0.28 (−0.22, 0.77)	0.34 (−0.16, 0.83)	0.18 (−0.32, 0.67)
0.4 mg/g (HT)	0.11 (−0.38, 0.59)	0.51 (0.03, 0.99)	0.23 (−0.25, 0.72)	0.65* (0.16, 1.14)	0.33 (−0.16, 0.82)	0.12 (−0.36, 0.6)
Usual Brand group as reference group (secondary analysis):
15.8 mg/g	−0.06 (−0.55, 0.42)	−0.04 (−0.53, 0.45)	−0.14 (−0.63, 0.35)	−0.16 (−0.65, 0.33)	−0.43 (−0.92, 0.06)	−0.2 (−0.69, 0.29)
5.2 mg/g	−0.07 (−0.55, 0.42)	0.25 (−0.24, 0.73)	−0.13 (−0.62, 0.36)	−0.03 (−0.52, 0.46)	−0.3 (−0.79, 0.2)	−0.19 (−0.68, 0.29)
2.4 mg/g	−0.05 (−0.53, 0.44)	0.3 (−0.18, 0.79)	−0.06 (−0.55, 0.44)	0.08 (−0.42, 0.57)	−0.06 (−0.56, 0.44)	0.02 (−0.47, 0.51)
1.3 mg/g	0.14 (−0.34, 0.62)	0.48 (0, 0.96)	0.1 (−0.38, 0.59)	0 (−0.49, 0.49)	−0.21 (−0.7, 0.28)	−0.02 (−0.5, 0.47)
0.4 mg/g	0.04 (−0.45, 0.52)	0.32 (−0.17, 0.81)	−0.04 (−0.53, 0.46)	0.12 (−0.38, 0.61)	−0.09 (−0.59, 0.4)	−0.02 (−0.52, 0.47)
0.4 mg/g (HT)	0.04 (−0.44, 0.52)	0.47 (−0.01, 0.95)	0.09 (−0.39, 0.57)	0.49 (0.01, 0.97)	−0.1 (−0.59, 0.38)	−0.08 (−0.56, 0.4)

^*indicates p < 0.01.

Mean differences (95% confidence interval) are reported.