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. 2017 Mar 23;7:369. doi: 10.1038/s41598-017-00473-5

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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AngII promoted the anticoagulant effects of rivaroxaban in KKAy mice. Mice were administered orally with rivaroxaban (RivX, 5 mg/kg body weight/day), or infused with AngII (1,500 ng/kg/min), or co-treated with RivX and AngII for 2 weeks. (a) Under isoflurane anesthesis, bleeding time was assessed. Blood was collected by cardiac puncture to determine the plasma levels of thrombin-antithrombin (TAT) complex (b), tissue factor (TF) (c), and TF pathway inhibitor (TFPI) (d), as well as the plasma activities of TF (e) and TFPI (f). The bars show the mean ± SEM (n = 6 to 8). ^* P < 0.05, compared with the KKAy blank group; ^# P < 0.05, compared with the RivX treatment group; ^& P < 0.05, compared with the AngII treatment group.