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. 2017 Mar 27;37(5):2575–2582. doi: 10.3892/or.2017.5530

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Copyright: © Zhu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SLC3A2 regulates the PI3K/AKT signaling pathway. (A and B) PathScan Intracellular Signaling array kit was used to analyze the signaling pathways influenced by knockdown of SLC3A2 expression in the MNNG/HOS and U2OS cells. (C and D) Diagrams showing the mean gray value of 18 key signaling molecules revealed that the p-Akt (Ser473) is downregulated by knockdown of SLC3A2 expression in both the MNNG/HOS and U2OS cell lines. (E) Western blot analysis of p-PI3K (Tyr607) and p-Akt (Ser473) in MNNG/HOS and U2OS cells transfected with si-NC and si-SLC3A2. Data are representative of three independent experiments. *P<0.05, by Students t-test.