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. 2017 Mar 24;7:409. doi: 10.1038/s41598-017-00466-4

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Bone tissue regeneration is accelerated by overexpression miR-503 therapy in DO animal model. (A) From HE staining of lengthened tibia in sagittal section, most of the regenerated bone tissues were mature in distraction gap in miR-503 overexpression group, while lots of cartilaginous callus still could be found in distracted gap in control group. (B) From Goldner’s trichrome staining, result showed that bone remodeling was vigorous in miR-503 overexpression group while lots of cartilage cells and fiber tissues still could be found in the distraction area. (Scale Bar = 150 μm). (C) Calcein (green) and Xylenol (orange) were subcutaneously injected into the rats at day 15 and day 43 separately. Vertical interval of the lines represented the amount of newly formed bone between the injection interphase. Result indicated miR-503 overexpression could promote mineralization of newly formed bone. (Scale Bar = 100 μm). (D) The dynamic histomorphometric parameters including MAR and MS/BS were found higher in miR-503 overexpression group than that in control group. (n = 5 each group, *P < 0.05).