Table 6.
Associations of lipid combinations with coronary severity using Logistic regression analysis.
| GS (0) | GS (1–23) | GS (≥24) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | P for trend | 1 | 2 | 3 | P for trend | ||
| Total | |||||||||
| TC + apoB | Reference | 0.87[0.56–1.35] | 1.15[0.74–1.79] | 1.39[1.04–1.87] | 0.018 | 0.82[0.51–1.32] | 1.24[0.79–1.95] | 1.57[1.16–2.13] | 0.002 |
| TC + Lp(a) | Reference | 1.03[0.71–1.47] | 0.99[0.69–1.43] | 1.39[0.99–1.42] | 0.084 | 1.27[0.87–1.86] | 1.24[0.85–1.81] | 1.61[1.11–2.32] | 0.017 |
| TC + PCSK9 | Reference | 1.25[0.87–1.80] | 1.24[0.85–1.79] | 1.38[0.98–1.94] | 0.082 | 1.42[0.97–2.09] | 1.63[1.11–2.40] | 1.78[1.24–2.56] | 0.001 |
| TC + apoC3 | Reference | 0.84[0.54–1.31] | 0.98[0.63–1.52] | 1.53[0.91–1.52] | 0.102 | 1.08[0.71–1.45] | 0.96[0.60–1.49] | 1.82[1.07–3.11] | 0.048 |
| HDL-C + apoA1 | Reference | 0.92[0.60–1.42] | 0.97[0.63–1.49] | 0.94[0.71–1.26] | 0.728 | 0.79[0.52–1.23] | 0.94[0.61–1.44] | 0.64[0.47–0.86] | 0.005 |
| LDL-C + apoB | Reference | 1.17[0.76–1.81] | 1.52[0.99–2.33] | 1.40[1.04–1.88] | 0.017 | 1.38[0.88–2.18] | 1.43[0.91–2.26] | 1.75[1.29–2.37] | <0.001 |
| LDL-C + Lp(a) | Reference | 0.97[0.67–1.39] | 0.93[0.65–1.34] | 1.39[0.99–1.95] | 0.086 | 1.38[0.94–2.01] | 1.12[0.76–1.64] | 1.83[1.28–2.62] | 0.004 |
| LDL-C + PCSK9 | Reference | 1.16[0.81–1.67] | 1.13[0.79–1.63] | 1.39[0.99–1.95] | 0.077 | 1.70[1.16–2.49] | 1.63[1.11–2.41] | 2.07[1.44–2.98] | <0.001 |
| LDL-C + apoC3 | Reference | 1.18[0.76–1.82] | 1.37[0.89–2.11] | 1.40[0.88–2.22] | 0.117 | 1.45[0.93–2.24] | 1.25[0.81–1.77] | 1.74[1.09–2.78] | 0.044 |
| Non-HDL-C + apoB | Reference | 0.68[0.43–1.07] | 1.01[0.65–1.56] | 1.35[1.01–1.80] | 0.030 | 0.97[0.61–1.53] | 0.83[0.51–1.34] | 1.75[1.29–2.37] | <0.001 |
| Non-HDL-C + Lp(a) | Reference | 1.03[0.72–1.48] | 1.06[0.74–1.51] | 1.37[0.96–1.95] | 0.099 | 1.50[1.03–2.19] | 1.18[0.80–1.73] | 1.97[1.36–2.86] | 0.002 |
| Non-HDL-C + PCSK9 | Reference | 1.10[0.77–1.59] | 1.13[0.78–1.63] | 1.31[0.94–1.85] | 0.13 | 1.88[1.28–2.76] | 1.73[1.17–2.57] | 2.18[1.51–3.15] | <0.001 |
| Non-HDL-C + apoC3 | Reference | 1.02[0.65–1.60] | 1.18[0.76–1.85] | 1.59[0.93–2.71] | 0.076 | 1.46[0.92–2.33] | 1.08[0.67–1.74] | 2.46[1.43–4.25] | 0.018 |
| ApoA1 + largeHDL-C | Reference | 1.07[0.68–1.69] | 0.67[0.41–1.09] | 0.94[0.64–1.38] | 0.514 | 1.13[0.73–1.75] | 0.66[0.42–1.06] | 0.53[0.36–0.78] | 0.001 |
| ApoB + Lp(a) | Reference | 1.06[0.74–1.52] | 0.90[0.62–1.29] | 1.59[1.12–2.27] | 0.031 | 1.36[0.93–1.98] | 1.10[0.75–1.60] | 1.93[1.33–2.80] | 0.003 |
| ApoB + PCSK9 | Reference | 1.16[0.81–1.67] | 0.98[0.68–1.42] | 1.54[1.10–2.17] | 0.029 | 1.48[1.01–2.17] | 1.39[0.95–2.05] | 2.07[1.45–2.98] | <0.001 |
| ApoB + apoC3 | Reference | 1.36[0.88–2.11] | 1.41[0.91–2.16] | 1.65[1.02–2.66] | 0.047 | 1.72[1.10–2.68] | 1.44[0.88–2.21] | 1.86[1.14–3.04] | 0.039 |
| ApoB + sdLDL-C | Reference | 1.17[0.71–1.92] | 1.08[0.67–1.76] | 1.20[0.80–1.78] | 0.408 | 1.48[0.89–2.46] | 1.45[0.88–2.37] | 1.93[1.29–2.89] | 0.002 |
| PCSK9 + sdLDL-C | Reference | 0.81[0.52–1.27] | 1.02[0.63–1.64] | 1.01[0.64–1.59] | 0.773 | 1.23[0.77–1.96] | 1.70[1.04–2.78] | 1.77[1.10–2.84] | 0.008 |
| ApoC3 + sdLDL-C | Reference | 1.00[0.63–1.58] | 0.98[0.62–1.55] | 1.40[0.78–2.51] | 0.406 | 1.19[0.73–1.92] | 1.53[0.95–2.45] | 2.21[1.22–4.00] | 0.005 |
| Men | |||||||||
| TC + apoB | Reference | 0.75[0.41–1.36] | 1.16[0.66–2.02] | 1.28[0.87–1.89] | 0.169 | 0.69[0.37–1.28] | 1.26[0.72–2.21] | 1.61[1.01–1.13] | 0.010 |
| TC + Lp(a) | Reference | 0.94[0.59–1.50] | 1.16[0.74–1.84] | 1.46[0.92–2.31] | 0.095 | 1.22[0.77–1.93] | 1.31[0.83–2.08] | 1.72[1.08–2.73] | 0.023 |
| TC + PCSK9 | Reference | 1.08[0.69–1.69] | 1.24[0.76–2.01] | 1.27[0.81–2.00] | 0.245 | 1.29[0.82–2.03] | 1.72[1.06–2.79] | 1.87[1.20–2.94] | 0.003 |
| TC + apoC3 | Reference | 0.62[0.34–1.13] | 0.83[0.47–1.46] | 1.51[0.74–3.10] | 0.239 | 0.85[0.47–1.52] | 0.72[0.41–1.29] | 1.83[0.90–3.71] | 0.263 |
| HDL-C + apoA1 | Reference | 0.89[0.43–1.51] | 0.98[0.70–1.62] | 0.92[0.66–1.31] | 0.841 | 0.74[0.37–1.21] | 0.82[0.49–1.33] | 0.56[0.31–0.94] | 0.035 |
| LDL-C + apoB | Reference | 1.00[0.57–1.77] | 1.42[0.82–2.45] | 1.28[0.87–1.89] | 0.159 | 1.25[0.71–2.20] | 1.25[0.71–2.21] | 1.85[1.26–2.73] | 0.002 |
| LDL-C + Lp(a) | Reference | 0.96[0.60–1.52] | 1.18[0.74–1.87] | 1.44[0.91–2.27] | 0.097 | 1.47[0.93–2.32] | 1.24[0.77–2.00] | 2.06[1.31–3.25] | 0.005 |
| LDL-C + PCSK9 | Reference | 1.01[0.64–1.57] | 1.12[0.70–1.82] | 1.31[0.83–2.05] | 0.239 | 1.59[1.01–2.49] | 1.63[1.01–2.66] | 2.30[1.46–3.62] | <0.001 |
| LDL-C + apoC3 | Reference | 1.00[0.56–1.80] | 1.24[0.71–2.15] | 1.41[0.76–2.61] | 0.211 | 1.41[0.80–2.51] | 1.00[0.56–1.74] | 1.86[1.01–3.41] | 0.148 |
| Non-HDL-C + apoB | Reference | 0.64[0.36–1.12] | 0.93[0.53–1.65] | 1.28[0.87–1.90] | 0.172 | 0.85[0.49–1.48] | 0.68[0.37–1.26] | 1.85[1.25–2.73] | 0.003 |
| Non-HDL-C + Lp(a) | Reference | 0.93[0.59–1.48] | 1.14[0.72–1.83] | 1.45[0.91–2.32] | 0.095 | 1.44[0.91–2.28] | 1.18[0.73–1.91] | 2.18[1.36–3.49] | 0.004 |
| Non-HDL-C + PCSK9 | Reference | 1.09[0.70–1.71] | 1.28[0.78–2.11] | 1.26[0.80–1.98] | 0.256 | 1.84[1.17–1.17] | 1.94[1.17–3.22] | 2.36[1.50–3.72] | <0.001 |
| Non-HDL-C + apoC3 | Reference | 0.77[0.41–1.45] | 0.94[0.51–1.71] | 1.77[0.83–3.78] | 0.129 | 1.15[0.62–2.13] | 0.80[0.43–1.49] | 2.72[1.28–5.76] | 0.059 |
| ApoA1 + largeHDL-C | Reference | 1.11[0.61–2.00] | 0.42[0.22–0.81] | 0.77[0.46–1.29] | 0.137 | 1.41[0.81–2.49] | 0.55[0.30–1.02] | 0.48[0.28–0.82] | 0.004 |
| ApoB + Lp(a) | Reference | 1.02[0.64–1.61] | 1.02[0.64–1.62] | 1.77[1.10–2.84] | 0.034 | 1.41[0.89–2.23] | 1.19[0.74–1.89] | 2.21[1.37–3.55] | 0.004 |
| ApoB + PCSK9 | Reference | 1.16[0.75–1.82] | 1.05[0.65–1.71] | 1.55[0.98–2.46] | 0.101 | 1.58[1.01–2.48] | 1.60[1.00–2.59] | 2.36[1.49–3.75] | <0.001 |
| ApoB + apoC3 | Reference | 1.40[0.78–2.54] | 1.43[0.82–2.50] | 1.83[0.97–3.48] | 0.081 | 1.82[1.02–3.24] | 1.25[0.72–2.20] | 2.05[1.09–3.86] | 0.117 |
| ApoB + sdLDL-C | Reference | 1.22[0.62–2.38] | 1.01[0.55–1.84] | 1.30[0.77–2.22] | 0.407 | 1.66[0.86–3.21] | 1.31[0.72–2.38] | 2.11[1.25–3.56] | 0.009 |
| PCSK9 + sdLDL-C | Reference | 0.87[0.49–1.55] | 1.16[0.65–2.06] | 0.99[0.54–1.79] | 0.825 | 1.35[0.76–2.41] | 1.73[0.97–3.09] | 1.78[1.00–3.22] | 0.033 |
| ApoC3 + sdLDL-C | Reference | 0.93[0.50–1.72] | 0.94[0.49–1.79] | 1.46[0.66–3.23] | 0.418 | 0.89[0.48–1.65] | 1.26[0.67–2.38] | 1.85[0.85–4.05] | 0.055 |
Multiple ordinal logistic regression analyses were performed, ORs [95% CIs] were showed with adjustment for age, gender, hypertension, HbA1c, current smoking and hs-CRP.
GS status was the dependent variable with the group of GS = 0 as reference status. Lipid categories of the two biomarkers were the independent variable, and 4 groups were included based on the medians of their levels: low/low (less than the medians of both), high/low (greater than or equal to the median of the prior but less than the median of the posterior), low/high (less than the median of the prior but greater than or equal to the median of the posterior) and high/high (greater than or equal to both the medians). The OR of low/low was 1 and not shown in the Table.
The medians of their levels were 4.77 mmol/L (TC), 1.04 mmol/L (HDL-C), 3.07 mmol/L (LDL-C), 3.67 mmol/L (non-HDL-C), 1.30 g/L (apoA1), 1.01 g/L (apoB), 123.34 mg/L [Lp(a)], 228.48 ng/ml (PCSK9), 82.23 μg/ml (apoC3), 12.0 mg/dl (large HDL-C), 5.0 mg/dl (sdLDL-C) in total population and 4.66 mmol/L (TC), 0.98 mmol/L (HDL-C), 3.04 mmol/L (LDL-C), 3.66 mmol/L (non-HDL-C), 1.26 g/L (apoA1), 1.01 g/L (apoB), 112.48 mg/L [Lp(a)], 218.75 ng/ml (PCSK9), 78.43 μg/ml (apoC3), 11.0 mg/dl (large HDL-C), 5.0 mg/dl (sdLDL-C) in men.
The bold values indicated statistical significance and were bolded to improve the readability of the table.
Abbreviations as Table 1.