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. 2017 Mar 24;7:416. doi: 10.1038/s41598-017-00405-3

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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miR-140-5p is associated with chemoresistance and increased the chemoresistance. (A) miR-140-5p expression was assessed in chemosensitive patients (n = 15) and chemoresistant patients (n = 15). (B) Representative photographs of IHC stained human osteosarcoma tissue specimens at a magnifcation of 200x. HMGN5 and BECN-1 were markedly up-regulated in chemoresistant patients. Columns, mean of intensity of the staining (n = 15). (C) The tumor volumes were calculated as V = length × width²/2 and measured at 1, 2, 3, 4, 5 weeks time points. (D) Representative photos for tumor isolated from the nude mice (n = 6). U2-OS/KD cells or control cells (Blank) were transplanted in the left and right side of the mice, respectively. P < 0.05, **P < 0.01 vs Blank.