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. 2017 Apr 3;7:546. doi: 10.1038/s41598-017-00431-1

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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VD3 modulates miR-19a transcription in B cells. (A–C) The bars indicate the expression of VDR (A), cyp27b1 (B) and cyp24a1 (C) in peripheral B cells of healthy persons and AR patients. (D) The immune blots indicate a complex of VDR, RXR and calcitriol in peripheral B cells of AR patients at month 6 after the commerce of the therapy of SIT/VD3. (E) The bars indicate the levels of calcitriol, VDR, RXR and c-Myc at the miR-19a promoter locus. (F) The bars indicate the miR-19a levels in B cells after the treatment denoted on the X axis. (G) The immune blots show the VDR RNAi results in B cells. The data are representative of 3 independent experiments. Data of bars are presented as mean ± SD. *p < 0.01, compared with “0” month (E) or saline group (F). The full-length gels and blots are included in the supplementary information.