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. 2017 Mar 23;7:346. doi: 10.1038/s41598-017-00413-3

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© The Author(s) 2017

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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SGK1 regulates Na_V1.5 channel function. (A) Expression of SGK1-CA in HEK-Na_V1.5 cells leads to increase in I_Na density. Inset scale = vertical: 50 pA/pF, horizontal: 2 ms. (B) SGK1 activation leads to a hyperpolarizing shift of steady state activation and inactivation curves for I_Na. (C) Peak sodium currents are increased with expression of SGK1-CA while inhibition of SGK1 by the dominant negative kinase dead SGK-1 (SGK1-DN) leads to decrease in I_Na density (*p-value < 0.005 by one way ANOVA, n = 5–11 for each condition). (D) Mutation of a novel SGK1 putative site T1590A leads to abrogation of the increase in I_Na with SGK1 activation. (E) Quantification of peak sodium currents (NS = non-significant change, n = 3–5 for each condition).