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. 2017 Apr 3;7:567. doi: 10.1038/s41598-017-00505-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Influence of a HFD on the reproductive system of mice can be recovered by stopping the HFD. (A) Representative picture of G8C4H, G12H and G12C mice. Comparison of time-dependent increases in bodyweight between G4H8C, G12H and G12C mice (n = 10 in each group). (B) Epididymal adipose tissue and EAT/BW of G4H8C, G12H and G12C mice. (C) Food intake in three groups. (D) Haematoxylin and eosin-stained testicular sections from G4H8C, G12H and G12C mice. Scale bars = 50 μm. (E) Testosterone levels, Spermatic parameters, including sperm concentration, mobility and rate of abnormal sperm, and the number of offspring in each group. (F) Germ cell apoptosis was tested using a TUNEL assay in three groups, and the apoptosis index was determined. (G) Serum and testis homogenates tested for IL1β (ELISA). (H) Immunohistochemical detection of the macrophage-specific antigen F4/80 (black arrows) in testes from G4H8C, G12H and G12C mice and the ratio positive cell between these groups. (I) Inflammasome-related gene expression in these three groups (*P < 0.05 compared with the G12H mice group). (J) Inflammasome protein expression in these three groups. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01. ***P < 0.001; n.s. non-significant difference.