Figure 5.

Alprazolam enhances GABA’s ability to promote human islet cell replication. Human islets were incubated with a dose range of GABA together with alprazolam (100 ng/ml) for 4 days in the presence of ³H thymidine. Data shown are the average rate of proliferation relative to that of cultures with medium alone (designated as 1) in a representative study. N = two independent studies with triplicate cultures. The results were very similar in both studies. ^††p < 0.01 and ^†††p < 0.001for GABA, or GABA + alprazolam vs. control medium alone; *p < 0.05 and ***P < 0.01 for GABA + alprazolam vs. GABA alone, determined by Student T-test.