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Suppression of P. gingivalis antigen-induced inflammatory cytokine release in THP-1 by hBD3. PMA-primed THP-1 cells were pretreated with various doses of hBD3 for 30 min and stimulated with 1,000 ng/mL of P. gingivalis antigen for 23 h. The culture supernatants were collected and subjected to IL-1β- and TNF-α-specific ELISAs. The data are presented as the means SD (n = 3) of three independent experiments; **p < 0.01, *p < 0.05.
