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. 2017 Apr 6;7:698. doi: 10.1038/s41598-017-00652-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Endocrine/immune activation in response to complete Freund’s adjuvant (CFA) injection. (a) Heatmaps showing the overall cytokine response to CFA-injection in the hypothalamus, hippocampus, and spleen. Columns represent severity states (control, Adj/NA, Adj/M-M, Adj/S), split by colony, as indicated. Rows represent mean cytokine levels (z-scored data) by severity state, within each tissue. Colors indicate deviations from the mean of zero, as indicated in the colour key. (b–d) Graphical representation of the correlations between the experimental condition (colony, AA severity) and the subjects’ component scores for component 1 (Endocrine/Immune Response in Peripheral Tissue), 2 (Proinflammatory Chemokine Response in Peripheral Tissue & Brain), and 3 (Central Balance of Pro-/Anti-Inflammatory Cytokines) from the CPCA. *p < 0.05; **p < 0.01; ***p < 0.001. Control: saline-injected; Adj/NA: no clinical signs of AA following CFA injection; Adj/M-M: mild-moderate AA, clinical score ≥1, <8; Adj/S: severe AA, clinical score ≥8.