Table 2.
Associations of mutations with clinicopathological characteristics.
| Variables | Mutational status | Total N | OR | 95% CI | P-value | |
|---|---|---|---|---|---|---|
| Wildtype N (%) | Mutated N (%) | |||||
| BRAF | 50 (50%) | 50 (50%) | ||||
| Histological subtype | ||||||
| LMM | 5 (55.6) | 4 (44.4) | 9 | 0.5 | 0.2–0.8 | 0.013 |
| SSM | 29 (41.2) | 40 (54.8) | 69 | |||
| NM | 8 (57.1) | 6 (42.9) | 14 | |||
| ALM | 8 (100) | 0 (0) | 8 | |||
| KIT | 95 (95%) | 5 (5%) | ||||
| Histological subtype | ||||||
| LMM | 9 (100) | 0 (0) | 9 | |||
| SSM | 68 (98.5) | 1 (1.5) | 69 | 4.4 | 1.6–12.1 | 0.004 |
| NM | 13 (92.9) | 1 (7.1) | 14 | |||
| ALM | 5 (62.5) | 3 (37.5) | 8 | |||
| Ulceration | ||||||
| No | 73 (98.6) | 1 (1.4) | 74 | 13.3 | 1.4–124.9 | 0.024 |
| Yes | 22 (84.6) | 4 (15.4) | 26 | |||
| Tumor stage | ||||||
| I–II | 79 (97.5) | 2 (2.5) | 81 | 7.4 | 1.1–47.9 | 0.036 |
| III–IV | 16 (84.2) | 3 (15.8) | 19 | |||
| PREX2 | 86 (86%) | 14 (14%) | ||||
| Mitosis | ||||||
| <1 | 45 (93.8) | 3 (6.3) | 48 | 4.0 | 1.0–15.4 | 0.042 |
| ≥1 | 41 (78.8) | 11 (21.2) | 52 | |||
| GRIN2A | 87 (87%) | 13 (13%) | ||||
| Sun related site | ||||||
| Non exposed | 20 (95.2) | 1 (4.8) | 21 | |||
| Ocasionally exposed | 56 (88.9) | 7 (11.1) | 63 | 3.2 | 1.1–9.2 | 0.026 |
| Usually exposed | 11 (68.8) | 5 (31.3) | 16 | |||
| Mitosis | ||||||
| <1 | 46 (95.8) | 2 (4.2) | 48 | 6.2 | 1.3–29.5 | 0.023 |
| ≥1 | 41 (78.8) | 11 (21.2) | 52 | |||
| RAC1 | 92 (92%) | 8 (8%) | ||||
| Sun related site | ||||||
| Non exposed | 21 (100) | 0 (0) | 21 | |||
| Ocasionally exposed | 59 (93.7) | 4 (6.3) | 63 | 5.9 | 1.5–23.2 | 0.011 |
| Usually exposed | 12 (75) | 4 (25) | 16 | |||
| NF1 | 92 (92%) | 8 (8%) | ||||
| Breslow | ||||||
| ≤1 | 45 (95.7) | 2 (4.3) | 47 | |||
| 1–2 | 21 (100) | 0 (0) | 21 | 2.2 | 1.1–4.3 | 0.025 |
| 2–4 | 15 (78.9) | 4 (21.1) | 19 | |||
| >4 | 10 (76.9) | 3 (23.1) | 13 | |||
| Ulceration | ||||||
| No | 72 (97.3) | 2 (2.7) | 74 | 26.9 | 3.1–232.1 | 0.003 |
| Yes | 19 (73.1) | 7 (26.9) | 26 | |||
| Growth rate | ||||||
| SGM | 74 (97.3) | 2 (2.7) | 76 | 12.2 | 2.3–65.4 | 0.004 |
| FGM | 17 (70.8) | 7 (29.2) | 19 | |||
LMM: Lentigo maligna melanoma; SSM: Superficial spreading melanoma; NM: Nodular melanoma; ALM: Acral lentiginous melanoma; SGM: Slow growing melanoma; FGM: Fast growing melanoma.