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. 2017 May 8;12:3533–3545. doi: 10.2147/IJN.S136599

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© 2017 Yeom et al. This work is published and licensed by Dove Medical Press Limited

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Correlations between in vitro dissolution and in vivo oral BA.

Notes: (A) DE for 2 h in vitro versus AUC_0–24 in vivo; (B) DEC in vitro versus AEC in vivo. ●, VST powder; △, SMEDDS (320 mg); ■, S-SMEDDS_LQ; ◇, S-SMEDDS_RQ. Values are presented as mean ± SD (n=3–7).

Abbreviations: AEC, dissolution enhancing capacity per unit quantity; AUC, area under the curve; BA, bioavailability; DE, dissolution efficiency; DEC, dissolution enhancing capacity per unit quantity; SMEDDS, self-microemulsifying drug delivery system; S-SMEDDS_LQ, supersaturable self-microemulsifying drug delivery system in large quantity; S-SMEDDS_RQ, supersaturable self-microemulsifying drug delivery system in reduced quantity; SD, standard deviation; VST, valsartan.