Table 1.
Solubility of VST in selected excipients
| Excipient | Solubility (mg/mL) |
|---|---|
| Oil | |
| Olive oil | <0.01 |
| Corn oil | <0.01 |
| Lauroglycol™ 90 | 176.5±7.1 |
| Capryol™ 90 | 217.8±3.1 |
| Capmul® MCM | 236.6±23.8 |
| Surfactant | |
| Cremophor EL | 121.4±7.4 |
| Labrasol | 125.3±9.5 |
| Tween® 20 | 284.0±12.7 |
| Tween® 80 | 232.6±20.9 |
| Cosurfactant | |
| PEG 400 | 152.5±11.3 |
| Propyleneglycol | 299.6±12.1 |
| Tetraglycol | 316.3±50.5 |
| Transcutol® P | 328.2±21.2 |
| Hydrophilic polymera | |
| HPMC E2910 | 0.32±0.01 |
| PVP K90 | 0.23±0.00 |
| PEG 6000 | 0.14±0.02 |
| Amphiphilic polymera | |
| Poloxamer 407 | 3.24±0.06 |
| Soluplus® | 0.97±0.01 |
| Vitamin E TPGS | 2.08±0.03 |
Notes:
a
1% (w/v) solution of polymers was used. Values are presented as mean ± SD (n=3).
Abbreviations: HPMC, hydroxypropyl methylcellulose; PEG, polyethylene glycol; PVP, polyvinylpyrrolidone; SD, standard deviation; Vitamin E TPGS, d-α-tocopheryl polyethylene glycol 1000 succinate; VST, valsartan.