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. 2017 May 8;12:3533–3545. doi: 10.2147/IJN.S136599

Table 1.

Solubility of VST in selected excipients

Excipient Solubility (mg/mL)
Oil
 Olive oil <0.01
 Corn oil <0.01
 Lauroglycol™ 90 176.5±7.1
 Capryol™ 90 217.8±3.1
 Capmul® MCM 236.6±23.8
Surfactant
 Cremophor EL 121.4±7.4
 Labrasol 125.3±9.5
 Tween® 20 284.0±12.7
 Tween® 80 232.6±20.9
Cosurfactant
 PEG 400 152.5±11.3
 Propyleneglycol 299.6±12.1
 Tetraglycol 316.3±50.5
 Transcutol® P 328.2±21.2
Hydrophilic polymera
 HPMC E2910 0.32±0.01
 PVP K90 0.23±0.00
 PEG 6000 0.14±0.02
Amphiphilic polymera
 Poloxamer 407 3.24±0.06
 Soluplus® 0.97±0.01
 Vitamin E TPGS 2.08±0.03

Notes:

a

1% (w/v) solution of polymers was used. Values are presented as mean ± SD (n=3).

Abbreviations: HPMC, hydroxypropyl methylcellulose; PEG, polyethylene glycol; PVP, polyvinylpyrrolidone; SD, standard deviation; Vitamin E TPGS, d-α-tocopheryl polyethylene glycol 1000 succinate; VST, valsartan.