Table 3.
Composition of S-SMEDDS and observed responses in the 3-LFD
| S-SMEDDS formulation | SMEDDS (mg; X1) | POL (%; X2) | Droplet size (nm; Y1) | Percent dissolved in 15 min (%; Y2) | Total quantity (mg; Y3) |
|---|---|---|---|---|---|
| 1 | 100 | 1 | 658.1±60.5 | 7.08±0.00 | 101 |
| 2 | 100 | 5.5 | 267.2±15.2 | 17.71±2.49 | 105.5 |
| 3 | 100 | 10 | 214.8±26.6 | 24.59±2.91 | 110 |
| 4 | 250 | 1 | 440.7±41.9 | 20.15±1.35 | 252.5 |
| 5 | 250 | 5.5 | 191.3±5.8 | 46.05±0.23 | 263.75 |
| 6 | 250 | 10 | 152.7±0.4 | 81.53±5.83 | 275 |
| 7 | 400 | 1 | 169.0±16.8 | 72.79±6.31 | 404 |
| 8 | 400 | 5.5 | 142.0±2.8 | 89.40±0.70 | 422 |
| 9 | 400 | 10 | 130.6±4.3 | 95.20±2.86 | 440 |
| 10 | 250 | 5.5 | 207.2±10.1 | 42.15±2.41 | 263.75 |
| 11 | 250 | 5.5 | 180.6±7.9 | 49.50±1.54 | 263.75 |
Note: Values are presented as mean ± SD (n=3).
Abbreviations: POL, poloxamer 407; SMEDDS, self-microemulsifying drug delivery system; S-SMEDDS, supersaturable self-microemulsifying drug delivery system; SD, standard deviation; 3-LFD, 3-level factorial design.