Table 5.
Experimental and predicted values for two optimal S-SMEDDS
| Type | Composition | Response | Importance (+ to ++++) | Predicted value | Experimental value | Percentage prediction errora |
|---|---|---|---|---|---|---|
| S-SMEDDS_LQ | X1: 320 mg | Size (Y1) | + | 158.1 | 150.8±3.8 | −4.8 |
| X2: 10% (32 mg) | Dissolution (Y2) | ++++ | 82.6 | 90.2±2.5 | 8.4 | |
| Total quantity (Y3) | + | 351.5 | 352 | 0.1 | ||
| S-SMEDDS_RQ | X1: 131.5 mg | Size (Y1) | + | 177.9 | 187.8±5.5 | 5.3 |
| X2: 10% (13.15 mg) | Dissolution (Y2) | + | 39.2 | 39.0±9.3 | −0.5 | |
| Total quantity (Y3) | ++ | 144.8 | 144.6 | −0.1 |
Notes:
a
Calculated using the formula ([experimental value − predicted value]/experimental value) ×100 (%). Values are presented as the mean ± SD (n=3).
Abbreviations: S-SMEDDS, supersaturable self-microemulsifying drug delivery system; S-SMEDDS_LQ, S-SMEDDS in large quantity; S-SMEDDS_RQ, S-SMEDDS in reduced quantity; SD, standard deviation.