Table 2.
Results of biodistribution studies of 99mTc labelled GAR-NPs in B16F10 tumor-bearing mice at 2, 4, 6 and 8 h post injection time periods.
| Organ/Tissue | 99mTc Radiolabeled GAR-NPs | |||
|---|---|---|---|---|
| 2 h | 4 h | 6 h | 8 h | |
| Heart | 0.221 ± 0.066 | 0.199 ± 0.032 | 0.159 ± 0.066 | 0.145 ± 0.019 |
| Blood* | 0.710 ± 0.091 | 0.689 ± 0.078 | 0.520 ± 0.012 | 0.480 ± 0.091 |
| Liver | 31.310 ± 1.017 | 47.526 ± 0.868 | 48.675 ± 1.543 | 48.152 ± 1.261 |
| Lung | 1.563 ± 0.182 | 2.561 ± 0.338 | 3.124 ± 0.156 | 4.111 ± 0.165 |
| Spleen | 0.210 ± 0.039 | 0.351 ± 0.039 | 0.421 ± 0.123 | 0.512 ± 0.129 |
| Kidney | 2.360 ± 0.121 | 3.580 ± 0.589 | 1.960 ± 0.173 | 1.560 ± 0.192 |
| Intestine | 3.272 ± 0.673 | 7.693 ± 0.635 | 9.653 ± 0.820 | 10.918 ± 1.962 |
| Stomach | 0.185 ± 0.030 | 0.190 ± 0.030 | 0.185 ± 0.036 | 0.199 ± 0.046 |
| Urine | 19.193 ± 0.193 | 26.233 ± 1.047 | 22.912 ± 2.103 | 18.123 ± 1.126 |
| Muscle* | 0.056 ± 0.006 | 0.077 ± 0.002 | 0.076 ± 0.004 | 0.072 ± 0.003 |
| Tumor* | 0.221 ± 0.023 | 0.645 ± 0.006 | 0.649 ± 0.051 | 0.759 ± 0.063 |
| Tumor/muscle | 3.946 | 8.376 | 8.539 | 10.541 |
| Tumor/blood | 0.311 | 0.936 | 1.248 | 1.581 |
Results are expressed in percentage injected dose per organ/tissue (each value is the mean ± SEM of five animals per group). *Percent injected dose per gram.